Disadvantages of Polymeric Nanoparticles
Although polymeric nanoparticles have many advantages (such as various fabrication methods, versatile drug loading, and drug release methods), they still have some drawbacks. The main limitation is that some preparation methods use toxic organic solvents that could degrade certain drugs when they come into contact during the formulation process or could be hazardous to the environment as well as to the physiological system (Birnbaum et al. 2000). Other disadvantages include poor drug encapsulation for certain hydrophilic drugs and the possible drug leakage before reaching its target tissues and/or cells.
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