Nanotec 2005

Active Targeting Strategies in Cancer with a Focus on Potential Nanotechnology Applications

• Human Anatomy And Physiology Study Course
• High Blood Pressure Remedy
• How to Fight and Overcome Cancer

Randall J. Mrsny

3.1 Introduction...........................................................................................................................19

3.2 Nanoparticle Characteristics.................................................................................................20

3.2.1 Composition and Biocompatibility ........................................................................... 22

3.2.2 Derivitization.............................................................................................................23

3.2.3 Detection.................................................................................................................... 23

3.3 Nanoparticle Targeting..........................................................................................................24

3.3.1 Inherent Targeting.....................................................................................................24

3.3.2 Complicating Aspects...............................................................................................25

3.3.3 Safety Issues..............................................................................................................26

3.4 Targeting to Cancer Cells.....................................................................................................27

3.4.1 Cell Surface Properties..............................................................................................28

3.4.2 Metabolic Properties ................................................................................................. 29

3.5 Targeting to Tumors..............................................................................................................30

3.5.1 Aberrant Vasculature.................................................................................................30

3.5.2 Metabolic Environment.............................................................................................32

3.6 Fate of Nanoparticles............................................................................................................32

3.6.1 Site of Initial Application.........................................................................................33

3.6.2 Distribution to Specific Organs.................................................................................34

3.6.3 Intracellular Uptake and Fate....................................................................................34

3.7 Conclusions ........................................................................................................................... 35

References ...................................................................................................................................... 37

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