Porous Silicon
The attraction of placing active electronic circuit components into in-vivo drug delivery materials led to the exploration of elemental silicon as a biomaterial. In particular a porous form of Si produced by an electrochemical corrosion reaction has been of interest. Since the pioneering work of Canham and others in the late 90's demonstrating the biocompatibility and biodegradability of porous Si in vitro and in vivo 25-35 , this material has been under intensive investigation for controlled...
Surface Chemistry
Techniques used to associate proteins and polymers include covalent linkage and passive adsorption. Although covalent linkage is often more stable than simple adsorption, it is possible that the stability and function of the conjugates may be impaired. Covalent linkage requires the presence of functional groups on the surface of the substrate. Protein-carrier conjugates have been prepared through activation of hydroxyl, carboxyl, and amino groups FIGURE 14.7. Scanning electron micrograph of a...
Huvec Cell Culture
FIGURE 5.5. Schematic of a potential multi-phenotypic biosensor. Six different cell lines are isolated in hydrogel arrays in six different microfluidic channels. Several cellular assays can be performed using one array. Multi-phenotypic arrays offer the advantage of providing more information about cellular responses than existing arrays and lend themselves to miniaturization, which could lead to high degrees of multiplexing. Multi-phenotypic cell based biosensors show promise in the area of...